Evaluation of Gentamicin Ototoxicity in Newborn Infants

Authors

1 Department of Pediatrics, Neonatology Division, Karabuk University Faculty of Medicine, Karabuk, Turkey

2 Department of Pediatrics,Karabuk University Faculty of Medicine, Karabuk, Turkey.

Abstract

Introduction: The main purpose of this study was to demonstrate the effect of gentamicin on hearing tests in newborns treated with gentamicin in our NICU , and to contribute to the selection of antibiotics more consciously.
Material and Method: Infants who were hospitalized and followed up in the NICU of Karabük University Medical Faculty Hospital, Karabük , Turkey, between 01 December 2019 and 30 November 2020 were included in our study. . During the study period, 331 infants hospitalized in the NICU and meeting the inclusion criteria were included.The infants were divided into two groups, with and without gentamicin treatment, and their demographic characteristics, respiratory support treatment and hearing test results were retrospectively analyzed and the results were compared..Automated auditory brainstem response (ABR) was used for newborn hearing screening at discharge
Results: Demographically, maternal age and birth weight were found to be significantly lower in gentamicin patients. Delivery method and gestational age were similar between the two groups. While the rates of passing the first test in the ABR screening were higher in the gentamicin group (p=0.051), only 1 infant in the same  group  failed the ABR second screening. This infant was 34 weeks old, a fraternal twin born at 2200 g, and no hearing loss was found in the infant’s twin. When the anamnesis was observed in detail, the infants’ uncle manifested a history of hospitalization for the treatment of urinary tract infection in his youth. In the meantime, his history of amikacin treatment and consequent experience of sensorineural hearing loss was revealed.
Conclusion: We concluded that gentamicin does not affect the hearing test when it is not used in the short-term (5-7 days), extended dosing intervals (24-48 hours) and ototoxic drugs such as loop diuretics.

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