1 Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

2 Student Research Committee, Faculty of medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


Background:  Kawasaki disease (KD) is an acute vasculitis that affects small and medium-sized arteries. During the coronavirus disease 19 (COVID-19) pandemic, a significant increase in children with KD symptoms who had COVID-19 was reported, known as the multisystem inflammatory syndrome in children (MIS-C). We describe 2 cases of KD following the COVID-19.
Case presentation: Two 2.5 and 3.5-year-old boys presented to the Shahid Sadoughi Hospital with weakness, fever, nausea, and vomiting for several days. The other symptoms were maculopapular rash, cracked lips, erythematous palms, conjunctivitis, and lymphadenopathy. Respiratory symptoms were observed in none of them. The course of the disease was moderate to severe in both, and they were treated entirely.
Conclusions: COVID-19 infection in children may present without any respiratory symptoms. Thus, Pediatricians should consider these atypical presentations and not restrict COVID-19 tests only for patients with typical presentations to prevent missing such cases and irreversible complications.