1 Allergist and Clinical Immunologist Department of Allergy and Immunology, Rasool-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

2 Assistant Professor of Pediatric Cardiology, Iran University of Medical Sciences, Tehran, Iran.

3 pediatric department,Iran university of medical sciences

4 MD-General Surgeon, Gilan University of Medical Sciences, Rasht, Iran.


Objective: Asthma is a chronic inflammatory disease of the lead to hypertrophy and dilatation of the right ventricle. Aim of study to evaluate and compare left and right ventricular systolic and diastolic function of the heart based on echocardiographic criteria in children with moderate to severe asthma and non-asthmatic children referred to Hazrat Rasouland Firoozabadi Hospitals of Tehranin 2019.
Methods: In this case-control study, 50 patients with a definite diagnosis of moderate to severe asthma(case group) and 50 healthy individuals (control group) were studied and compared in terms of clinical and echocardiographic measures. Blood pressure, heart rate, body height and weight of all children were recorded. The patients who were >6 years underwent pulmonary function tests using spirometry. Conventional and TDI echocardiography was performed bya single experienced pediatric cardiologist on two groups blindly and echocardiographic data was collected.
Results: The results showed that the left ventricular stroke volume was significantly lower in patients with asthma. Also, in the right ventricular SV, significantly lower values were found in the group of patients under study than healthy individuals (P=0.01). The E/A ratio in both groups was higher than one with a mean and standard deviation of 1.72±0.26 in the case group compared to 1.92±0.32 which was not significantly different.
Conclusion: The results of this study showed that asthma can affect ventricular contraction in children. Contrary to previous studies and despite the observation of cardiac systolic dysfunction in patients with asthma, diastolic dysfunction in these patients was not observed even by tissue Doppler echocardiography.

Keywords: Asthma, Cardiac function, Echocardiography