Document Type : case report


1 Department of Neurosurgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Neurosurgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


We report the case of a 14-year-old girl with huge cervical intramedullary lipoma, who presented with spastic quadriparesis. Her MRI revealed an intramedullary lipoma extending from the craniovertebral junction to the sixth cervical vertebra.
There was no spinal dysraphism. Subtotal excision of tumor with primary dural closure and laminoplasty was performed from C3 to C6, which produced an improvement in the patient’s function.


  1. Caram PC, Scarcella G, Carton CA. Intradural lipomas of the spinal cord: with particular emphasis on the “intramedullary” lipomas. Journal of neurosurgery. 1957 1; 14(1):28-42.
  2. Pathi R, Kiley M, Sage M. Isolated spinal cord lipoma. Journal of clinical neuroscience. 2003 Nov 1; 10(6):692-4.
  3. Chagla AS, Balasubramaniam S, Goel A6H (2008) A massive cervicomedullary intramedullary spinal cord lipoma. J Clin Neurosci 15:817–820.
  4. Muthusubramanian V, Pande A, Vasudevan MC, Ramamurthi R. Concomitant cervical and lumbar intradural intramedullary lipoma. Surgical neurology. 2008 Mar 1; 69(3):314-7.
  5. Ahmed O, Zhang S, Thakur JD, Nanda A. Nondysraphic intramedullary cervical cord lipoma with exophytic component: Case report. Journal of neurological surgery reports. 2015 Jul; 76(1):e87.
  6. Rappaport H, Tadmor R, Brand N. Spinal intradural lipoma with intracranial extension. Pediatric Neurosurgery. 1982; 9(6):411-8.
  7. White WR, Fraser RA. Cervical spinal cord lipoma with extension into the posterior fossa. Neurosurgery. 1983 Apr 1; 12(4):460-2.
  8. Wood BP, Harwood-Nash DC, Berger P, Goske M. Intradural spinal lipoma of the cervical cord. American journal of roentgenology. 1985 Jul 1; 145(1):174-6.
  9. Mori K, Kamimura Y, Uchida Y, Kurisaka M, Eguchi S. Large intramedullary lipoma of the cervical cord and posterior fossa: Case report. Journal of neurosurgery. 1986 Jun 1; 64(6):974-6.
  10. McGillicuddy GT, Shucart W, Kwan ES. Intradural spinal lipomas. Neurosurgery. 1987 Sep 1; 21(3):343-6.
  11. Amornmarn R, Faillace WJ, Clayman DM, Lu L, Prempree T. Lipoma of cervical spinal cord and posterior fossa. Case report. The Journal of the Florida Medical Association. 1992 Jan 1; 79(1):27-30.
  12. Donati F, Vassella F, Kaiser G, Blumberg A. Intracranial lipomas. Neuropediatrics. 1992 Feb; 23(01):32-8.
  13. Crols R, Appel B, Klaes R. Extensive cervical intradural and intramedullary lipoma and spina bifida occulta of C1: a case report. Clinical neurology and neurosurgery. 1993 Mar 1; 95(1):39-43.
  14. Ur-Rahman N, Salih MA, Jamjoom AH, Jamjoom ZA. Congenital intramedullary lipoma of the dorsocervical spinal cord with intracranial extension: case report. Neurosurgery. 1994 Jun 1; 34(6):1081-3.
  15. Wilson JT, Shapiro RH, Wald SL. Multiple intradural spinal lipoma with intracranial extension. Pediatric neurosurgery. 1996; 24(1):5-7.
  16. Chaskis C, Michotte A, Geffray F, Vangeneugden J, Desprechins B, D'haens J. Cervical intramedullary lipoma with intracranial extension in an infant: Case illustration. Journal of neurosurgery. 1997 Sep 1; 87(3):472-.
  17. Kogler A, Orsolic K, Kogler V. Intramedullary lipoma of torso cervicothoracic spinal cord with intracranial extension and hydrocephalus. Pediatric neurosurgery. 1998; 28(5):257-60.
  18. Kai Y, Amano T, Inamura T, Matsushima T, Takamatsu M, Kai E, Fukui M. An infant with an intradural lipoma of the cervical spine extending into the posterior fossa. Journal of clinical neuroscience. 2003 Jan 1; 10(1):127-30.
  19. Kim CH, Wang KC, Kim SK, Chung YN, La Choi Y, Chi JG, Cho BK. Spinal intramedullary lipoma: report of three cases. Spinal cord. 2003 May; 41(5):310-5.
  20. Feuvre DL, Semple PL, Peter JC. Intradural cervical lipomas with intracranial extension: a management strategy based on a case report and review of the literature. British journal of neurosurgery. 2004 Jan 1; 18(4):385-8.
  21. Bhatoe HS, Singh P, Chaturvedi A, Sahai K, Dutta V, Sahoo PK. Nondysraphic intramedullary spinal cord lipomas: a review. Neurosurgical focus. 2005 Feb 1; 18(2):1-5.
  22. Shahat AH, Obaideen AM, Ahmed K, Ahmed S. Intramedullary lipoma of the cervicodorsal spinal cord with intracranial extension: case report. Surgical neurology. 2006 May 1; 65(5):486-9.
  23. Mengual MV, Lloret PM, González AL, Simal JA, Garijo JA. Spinal cord lipoma without dysraphism in the infancy that extends intracranially. Case report and review of the literature. Surgical Neurology. 2009 May 1; 71(5):613-5.
  24. Şanlı AM, Türkoğlu E, Kahveci R, Şekerci Z. Intradural lipoma of the cervicothoracic spinal cord with intracranial extension. Child's Nervous System. 2010 Jun 1; 26(6):847-52.
  25. Fleming KL, Davidson L, Gonzalez-Gomez I, McComb JG. Nondysraphic pediatric intramedullary spinal cord lipomas: report of 5 cases. Journal of Neurosurgery: Pediatrics. 2010 Feb 1; 5(2):172-8.
  26. Meher SK, Tripathy LN, Jain H, Basu S. Nondysraphic cervicomedullary intramedullary lipoma. Journal of craniovertebral junction & spine. 2017 Jul; 8(3):271.
  27. Severino R, Severino P. Cervical intramedullary spinal cord lipoma. Surgical neurology international. 2017; 8.
  28. McCormick PC, Stein BM. Intramedullary tumors in adults. Neurosurgery Clinics. 1990 Jul 1; 1(3):609-30.
  29. Heary RF, Bhandari Y. Intradural cervical lipoma in a neurologically intact patient: case report. Neurosurgery. 1991 Sep 1; 29(3):468-72.
  30. Lee M, Rezai AR, Abbott R, Coelho DH, Epstein FJ. Intramedullary spinal cord lipomas. Journal of neurosurgery. 1995 Mar 1; 82(3):394-400.
  31. Ammerman BJ, Henry JM, De Girolami U, Earle KM. Intradural lipomas of the spinal cord: A clinicopathological correlation. Journal of neurosurgery. 1976 Mar 1; 44(3):331-6.
  32. Endoh M, Iwasaki Y, Koyanagi I, Hida K, Abe H. Spontaneous shrinkage of lumbosacral lipoma in conjunction with a general decrease in body fat: case report. Neurosurgery. 1998 Jul 1; 43(1):150-1.
  33. Kamel HA, Brennan PR, Farrell MA. Cervical epidural lipoblastomatosis: changing MR appearance after chemotherapy. American journal of neuroradiology. 1999 Mar 1; 20(3):386-9.
  34. Iwatsuki K. Intradural cervical lipoma with parenchymal marginal fibrous tissue: case report. Neurosurgery. 2006 Jul 1; 59(1):E208-discussion.