Document Type : original article


Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


Background: Type 1 Diabetes Mellitus (T1DM) is a chronic disorder that can cause microvascular and macrovascular damages in the long term as well as higher rates of mortality and morbidity in infectious diseases such as Covid-19. It has been discovered that the homeostasis of trace electrolytes like magnesium plays a crucial role in the pathogenesis of diabetes and its related complications. We aimed to determine serum magnesium levels in children with T1DM in northwest Iran and to evaluate the relationship between serum magnesium levels and glycemic control while also assessing several anthropometric and birth-time-related factors.
Methods: This cross-sectional study gathered data from 50 patients with T1DM and 50 other healthy subjects matched for age and gender living in the northwest area of Iran. These children were tested during their visits to the children’s hospital of Tabriz. Magnesium levels and environmental factors were measured in all study subjects.
Results: We found magnesium levels to be significantly lower in children with T1DM (p < 0.001). Hypomagnesemia was also seen in 58% of the case group, which was significantly more prevalent than the 6% in the control group (p <.001). We observed a negative correlation between serum magnesium and HbA1c levels in the diabetic group (r = -0.882, p <.001). No significant correlation was found between magnesium levels and duration of diabetes, age, and gender.
Conclusion: We concluded that total serum magnesium is lower in children with T1DM, which correlates with glycemic control. Further and more extended studies should be conducted to assess the effect of correction of serum magnesium in diabetic children with hypomagnesemia on glycemic control and the risk of diabetic complications.


  1. Cooke D, Rev LP, 2008 undefined. Type 1 diabetes mellitus in pediatrics. 2008;
  2. Katsarou A, Gudbjörnsdottir S, Rawshani A, Dabelea D, Bonifacio E, Anderson BJ, Anderson BJ, Jacobsen LM, Schatz DA, Lernmark A. Type 1 diabetes mellitus. Nat Rev Dis Prim 2017 31. 2017 Mar 30; 3(1):1–17.
  3. Malik FS, Taplin CE. Insulin therapy in children and adolescents with type 1 diabetes. Pediatric Drugs. 2014.
  4. Nambam B, Winter W, Schatz D. Type 1 diabetes. In: Encyclopedia of Endocrine Diseases. 2018.
  5. Zhang Y, Li Q, Xin Y, Lv W, Ge C. Association between serum magnesium and common complications of diabetes mellitus. Technol Health Care. 2018; 26(S1):S379–87.
  6. Slavcheva-Prodanova O, Konstantinova M, Tsakova A, Savova R, Archinkova M. Bone Health Index and bone turnover in pediatric patients with type 1 diabetes mellitus and poor metabolic control. Pediatr Diabetes. 2020 Feb 1; 21(1):88–97.
  7. Raisingani MG. Risk of Complications in Children with Type 1 Diabetes and Covid-19. J Endocr Soc. 2021 May 3; 5(Suppl 1):A62.
  8. Xu J, Xu W, Yao H, Sun W, Zhou Q, Cai L. Associations of Serum and Urinary Magnesium with the Pre-Diabetes, Diabetes and Diabetic Complications in the Chinese Northeast Population. PLoS One. 2013 Feb 13; 8(2).
  9. Gröber U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015 Sep 23; 7(9):8199.
  10. Al Alawi AM, Al Badi A, Al Huraizi A, Falhammar H. Magnesium: The recent research and developments. Adv Food Nutr Res. 2021 Jan 1; 96:193–218.
  11. Bjelakovic G, Sokolovic D, Ljiljana S, Kocic G, Jevtovic T, Stojanovic I, Ilic M, Bjelakovic LJ, Zivic S, Pavlovic D, Nikolić J, Basic J. Arginase activity and magnesium levels in blood of children with diabetes mellitus. J Basic Clin Physiol Pharmacol. 2009; 20(4):319–34.
  12. Uğurlu V, Binay C, Şimşek E, Bal C. Cellular Trace Element Changes in Type 1 Diabetes Patients. J Clin Res Pediatr Endocrinol. 2016 Jun 1; 8(2):180–6.
  13. Atabek ME, Kurtoglu S, Pirgon O, Baykara M. Serum magnesium concentrations in type 1 diabetic patients: relation to early atherosclerosis. Diabetes Res Clin Pract. 2006 Apr; 72(1):42–7.
  14. Abdalhady M, Kamel E, Abdel Rahman D, Kamel L, Abdelkader M. Status of serum magnesium in Egyptian children with type 1 diabetes and its correlation to glycemic control and lipid profile. Med (United States). 2016; 95(47).
  15. Weight-for-age (Internet). (Cited 2020 Dec 14). Available from:
  16. Ahmed MM, Helal SR. A Study of Serum Magnesium, Zinc, Copper and Glycohemoglobin In Children With Type 1 Diabetes Mellitus Abstract : Introduction : Subjects and Methods : Statistical Analysis : Results : 2002; 16(2).
  17. Salmonowicz B, Krzystek-Korpacka M, Noczyńska A. Trace elements, magnesium, and the efficacy of antioxidant systems in children with type 1 diabetes mellitus and in their siblings. Adv Clin Exp Med. 2014; 23(2):259–68.
  18. Marjanac I, Biljan B, Husarić E, Canecki-Varžić S, Pavela J, Lovrić R. Magnesium, zinc and iron serum levels as potential parameters significant for effective glycemic control in children with type 1 diabetes. Clin Diabetol. 2020 Feb 1; 9(3):161–6.
  19. Lin CC, Huang YL. Chromium, zinc and magnesium status in type 1 diabetes. Curr Opin Clin Nutr Metab Care. 2015 Oct 9; 18(6):588–92.
  20. Galli-Tsinopoulou A, Maggana I, Kyrgios I, Mouzaki K, Grammatikopoulou MG, Stylianou C, Karavanaki K. Association between magnesium concentration and HbA1c in children and adolescents with type 1 diabetes mellitus. J Diabetes. 2014; 6(4):369–77.
  21. Zargar A, Bashir M, Masoodi S, Laway B, J AW-SM, 2002 U. Copper, zinc and magnesium levels in type-1 diabetes mellitus.
  22. Derakhshan R, Balaee P, Darakhshan S, Masoodpoor N, Banihosseini SS. Lipid profile, thyroid function, and serum magnesium level in type I diabetic children. Minerva Pediatr. 2011 Feb; 63(1):27–33.
  23. Matthiesen G, Olofsson K, Rudnicki M. Ionized Magnesium in Danish Children with Type 1 Diabetes. Diabetes Care. 2004; 27(5):1216–7.
  24. Xu J, Xu W, Yao H, Sun W, Zhou Q, Cai L. Associations of Serum and Urinary Magnesium with the Pre-Diabetes, Diabetes and Diabetic Complications in the Chinese Northeast Population. PLoS One. 2013; 8(2).
  25. Inácio I, Azevedo T, Ferreira S, Rosinha P, Alves M, Dantas R, Guimarães J. Association Between Serum Magnesium and Glycemic Control, Lipid Profile and Diabetic Retinopathy in Type 1 Diabetes. J Endocr Soc. 2021 May 3; 5 (Supplement_1):A457–A457.
  26. Gragossian A, Bashir K, Friede R. Hypomagnesemia. Handb Inpatient Endocrinol. 2021 Sep 6; 345–52.