Document Type : original article

Authors

1 1.Department of Pediatric Pulmonology, Pediatrics Department, Emam Hossein children's hospital, Isfahan University of Medical Sciences, Isfahan, Iran. 2. Child Growth and Development Research Center, Research Institute for Primordial

2 Department of Clinical Pharmacy and Pharmacy Practice, Isfahan University of Medical Sciences, Isfahan, Iran.

3 1.Pediatrics Department, Emam Hossein children's hospital, Isfahan University of Medical Sciences, Isfahan, Iran 2. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable

4 Pediatrics Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

5 Pediatrics Department, Emam Hossein children's hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Introduction: Critically ill patients, especially those requiring admission to intensive care units (ICU), are at risk for stress-related gastrointestinal mucosal damage. We aimed to evaluate the frequency of proper prescription of antacid agents in a group of critically ill children admitted to PICU.



Material and methods: In this retrospective study, the medical records of children aged between 1 month to 15 years who were admitted in 2018-2019 to the PICU of Emam Hosein children's hospital, Isfahan, Iran, were reviewed. Demographic data, indications for PICU admission, principle diagnosis, the severity of the disease, incidence of bleeding during hospitalization, indications for stress ulcer prophylaxis, prescription of the antacid agents, type of antacid prescribed, and the patient finale outcome were recorded.



Results: We found that 204 (92.7%) of our patients received any kind of antacid agents for gastric SUP among the patients receiving SUP, 198 (90%) of the patients had an indication for SUP, and only 6 (2.7%) patients received unnecessary prophylaxis. In addition, 16 (7.2%) patients had no indication of receiving SUP and did not receive any prophylaxis. We also reviewed the type of antacid medication that was prescribed for SUP and found that 157 (72%) patients had received PPI, and 57 (30%) had received H2Ras.



Conclusions: The findings of the current study revealed that almost all of our study population who had an indication for prophylaxis of stress ulcer had appropriately received antacid agents. We suggest that there is a crucial need to conduct large prospective and multicentric studies in pediatric centers to prepare a universally accepted guideline for the prophylaxis of stress ulcers in the pediatric age group.

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