Document Type : original article
Authors
1 Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 General physician, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Biological sciences student, California state university, East Bay, Hayward, California, USA.
5 Assistant Professor of Pediatrics, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract
Background: The present study aimed at evaluating the demographic and laboratory factors associated with the recurrent seizure during hospitalization in the children with the first febrile seizure.
Methods: This cohort study was performed in Ghaem hospital, Mashhad University of Medical Sciences, Mashhad, Iran, from 2018 to 2019. Totally 483 admitted children aged 6-60 months with the first febrile seizure were included. The repetition of seizure during hospitalization was considered as incidence of recurrent seizure.
Results: Among 483 children with the first febrile seizure, recurrent seizure occurred in 57 patients (11.8%). The serum level of potassium, magnesium and calcium in children with recurrent seizure significantly was lower in comparison to the patients without repeated seizure. Complex seizure was the major risk factor for recurrent seizure (relative risk: 377.74, p=0.001). The risk of recurrent seizure decreased with the increase of serum level of potassium, calcium and magnesium. The risk of recurrent seizure increased with the increase of body temperature but not significantly.
Conclusion: The incidence rate of recurrent seizure in children with the first febrile seizure was 118 cases per 1000 population. Complex seizure was the main risk factor for the seizure recurrence. Higher serum levels of potassium, calcium and magnesium may decrease the risk of recurrent seizure.
Keywords
- Aguirre-Velázquez C, Huerta Hurtado AM, Ceja-Moreno H, Salgado-Hernández K, San Román-Tovar R, Ortiz-Villalpando MA, Molina-García A, Vargas-Ramírez G, López-Rivera J, Huerta-Albarrán R. 2019. Clinical guideline: febrile seizures, diagnosis and treatment. Revista Mexicana de Neurociencia. 20(2):97-103.
- Heydarian F, Bakhtiari E, Yousefi S, Heidarian M. 2018. The First Febrile Seizure: An Updated Study for Clinical Risk Factors. Iranian Journal of Pediatrics. 28(6) e69761.
- Heydarian F, Ashrafzadeh F, Kam S. 2009. Simple febrile seizure: the role of serum sodium levels in prediction of seizure recur-rence during the first 24 hours. 3(2):31-34.
- Gourabi HE, Bidabadi E, Cheraghali Pour F, Aarabi Y, Salamat F. 2012. Febrile seizure: demographic features and causative factors. Iranian journal of child neurology. 6(4):33.
- Tosun A, Koroglu G, Serdaroglu G, Polat M, Kurugol Z, Gokben S, Tekgul H. 2010. Ratios of nine risk factors in children with recurrent febrile seizures. Pediatric neurology. 43(3):177-82.
- Rizvi S, Ladino LD, Hernández-Ronquillo L, Téllez-Zenteno JF. 2017. Epidemiology of early stages of epilepsy: Risk of seizure recurrence after a first seizure. Seizure. 49:46-53.
- Leung AK, Hon KL, Leung TN. Febrile seizures: an overview. 2018. Drugs in context. 7.
- Bergey GK. 2016. Management of a first seizure. CONTINUUM: Lifelong Learning in Neurology. 22(1):38-50.
- Hauser WA, Beghi E. 2008. First seizure definitions and worldwide incidence and mortality. Epilepsia. 49:8-12.
- Vestergaard M, Basso O, Henriksen TB, Østergaard JR, Olsen J. 2002. Risk factors for febrile convulsions. Epidemiology. 282-7.
- Pavlidou E, Tsitiridou M, Kontopoulos E, Panteliadis CP. 2008. Which factors determine febrile seizure recurrence? A prospective study. Brain and Development. 30(1):7-13.
- Jamal MM, Ahmed W. 2015. To identify the factors affecting the risk of recurrent febrile seizures in Saudi children. Pakistan Armed Forces Medical Journal. 65(4):458-63.
- Naghavi M, Sobhani A, Kharazi H. 2000. Recurrence of attack and associated factors in children with febrile convulsion admitted in hospital. 9(36):22-27.
- Berg AT, Shinnar S. 1996. Complex febrile seizures. Epilepsia. 37(2):126-33.
- Thomas JE, Duffner PK, Shucard JL. 2004. Do serum sodium levels predict febrile seizure recurrence within 24 hours? Pediatric neurology. 31(5):342-4.
- Amouian S, Mohammadian S, Behnampour N, Tizrou M. 2013. Trace elements in febrile seizure compared to febrile children admitted to an academic hospital in Iran, 2011. Journal of clinical and diagnostic research: JCDR. 7(10):2231.
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