Document Type : review article


1 Golestan University of Medical Sciences

2 Department of Microbiology, Golestan University of Medical Sciences, Gorgan, Iran.


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provokes the host immune responses and induces severe respiratory syndrome by overreaction of immune cells. IL-1β is a pro-inflammatory cytokine highly associated with the related inflammation and cytokine storm, and several IL-1β antagonists are being used to treat cytokine release syndrome (CRS). Accordingly, some studies and clinical trials are investigating the effects of IL-1β antagonists for controlling Coronavirus disease 2019 (COVID-19) associated CRS. Here, we will review any interaction and association between IL-1β and SARS-CoV-2 infection.


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