Document Type : original article


1 Assistant Professor of Pediatrics Faculty of Medicine Mashhad University of Medical science. Mashhad Iran.

2 Student Research committee, Faculty of medicine Mashhad University of medical science, Mashhad Iran.

3 Professor of Pediatric Infectious Disease, Infection Control & Hand hygiene Research Center Faculty of medicine Mashhad University of medical science, Mashhad Iran.


Background: Urinary tract infection (UTI) in children is a serious condition that should be treated promptly and properly to prevent further complications. The most common causative agent of UTI is Escherichia coli (E.coli). This study aims to investigate the resistance profile of E.coli in pediatric cases of UTI.
Method: In this cross-sectional study, the positive cultures for E.coli in patients admitted in Dr. Sheikh Children Hospital of Mashhad, Iran, in Feb 2020 to Feb 2021 were assessed. The demographic factors including age and sex were excluded. Urinalysis was conducted to assess the number of bacteria (categorized as mild, moderate, and many) and the WBC count (categorized as > 5/hpf, > 10/hpf, and > 15/hpf). Furthermore, the antibiogram was consulted to assess the sensitivity and resistance to different antibiotics. Data was analyzed using SPSS software.
Results: In 160 children (20 males and 140 females) with the mean age of 24.00 ± 26.06 months, urinalysis showed that 22.5% were in the mild bacteriuria category, 21.3% in moderate bacteriuria, and 56.3% in the many bacteriuria category. For WBC count in urine, 12.5% had more than 5/hpf WBC, 11.9% had more than 10/hpf WBC, and 75.6% more than 15/hpf WBC. Regarding resistance, 4.5% of the patients were resistant to Amikacin, 6.5% to Nitrofurantoin, 20% to Ofloxacin, 35.1% to Ciprofloxacin, 50% to Gentamicin, 52.6% to Cefixime, 59.5% to Cefazolin, and 76.1% to Trimethoprim. The mean age and also the frequency of sex showed no significant difference between different severities of bacteriuria and WBC count in urine analysis (P > 0.05).
Conclusion: The highest E.coli resistance was to Trimethoprim, Cefazolin, Cefixime, Gentamicin, and Ciprofloxacin. The lowest resistance was to aAmikacin and Nitrofurantoin.


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