Document Type : original article


1 Mashhad University of Medical Sciences Professor of Pediatric Infectious Disease

2 Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 ,Pediatrics,medical science,Mashhad University of medical sciences



Antibiotic Resistance Profile of Pathogen Escherichia Coli in Children with Urinary Tract Infection

Urinary tract infection (UTI) in children is a serious condition that should be treated promptly and properly to prevent further complications. The most common causative agent of UTI is Escherichia coli (E.coli). However, studies regarding the E.coli resistance patterns have not been comprehensive, and further research is required. This study aims to investigate the resistance profile of E.coli in pediatric cases of UTI.

In this cross-sectional study, the positive cultures for E.coli in patients admitted in the Dr. Sheikh Children Hospital of Mashhad, Iran in Feb 2020 to Feb 2021 were assessed. The demographic factors including age and sex were excluded. The antibiogram was consulted to assess the sensitivity and resistance to different antibiotics.

In 160 children, 20 males and 140 females with the mean age of 24.00 ± 26.06 months, urinalysis showed that 22.5% were in the mild bacteriuria category, 21.3% in moderate bacteriuria, and 56.3% in the many bacteriuria categories. Regarding resistance, 4.5% of the patients were resistant to Amikacin, 6.5% to Nitrofurantoin, 20% to Ofloxacin, 35.1% to Ciprofloxacin, 50% to Gentamycin, 52.6% to Cefixime, 59.5% to Cefazolin, and 76.1% to Trimethoprim. Besides, the age and sex distribution, the number of bacteria, and WBC count in urinalysis had no significant difference between the susceptible and resistant cases (P > 0.05).

The highest E.coli resistance was to Trimethoprim, Cefazolin, Cefixime, Gentamycin, and Ciprofloxacin. The lowest resistance was to amikacin and nitrofurantoin. There was no significant difference in age and gender and also different severities of pyuria and bacteriuria between the susceptible and resistant cases.