Document Type : original article

Authors

1 Assistant Professor of Pediatrics, Clinical Research Development Unit Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.

2 Pediatrician, Shahrekord University of Medical Sciences, Shahrekord, Iran.

3 Assistant Professor of Neonatal and Prenatal Medicine, Department of Pediatrics, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.

4 Assistant Professor of Biostatistics, Department of Epidemiology and Biostatistics, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran.

5 Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran

10.22038/ijp.2022.67715.5048

Abstract

Introduction and aim: Vesicoureteral reflux (VUR) is a high-prevalence and dangerous urinary system disorder. So, this study was performed to investigate the comparison between intermittent and continuous administration of antibiotics for the treatment of children with VUR.

Methods: In this study, 27 children with VUR referred to a nephrology clinic were included in the study. Children received cephalexin at 15 mg/kg once daily for 6 months, and after a 48-hour washout period, children received cephalexin at 15 mg/kg intermittently every other day for 6 months. Before the start of each treatment period, kidney and urinary tract ultrasounds and urine tests and were performed for patients. In case of fever, dysuria, and frequent urination, urine test and culture were performed immediately, and in case of no symptoms, urine test and culture were performed monthly.

Results: Out of 27 children, 4 children (14.8%) had abnormal dimercaptosuccinic acid (DMSA) results, 18 (66.7%) had bladder reflux grade 4-5, 9 (33.3%) were less than 12 months, and 4 (14.8%) had recurrent urinary tract infections (UTI). The incidence of urinary tract infection in continuous and intermittent antibiotic treatment was similar and did not differ significantly (p>0.05). There were no ultrasound changes after the treatment period.

Conclusion: There was no difference between intermittent and continuous administration of antibiotics in the improvement of UTI symptoms in children with VUR. Therefore, the intermittent method can be used as a method with fewer toxicity or adverse effects in the treatment of these patients due to lower doses of antibiotics administration.

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