Document Type : systematic review


1 Department of Pediatrics, School of Medicine Emam Khomeini Hospital, Ilam University of Medical sciences, Ilam, Iran

2 Assistant Professor of Pediatric Intensive Care, Department of Pediatrics, School of Medicine Mofid Children's Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran

3 Msc of Neonatal Intensive Care Nursing, Lorestan University of Medical Sciences, Khorramabad, Iran,




Bacground: Despite the importance of diabetic nephropathy (DN), especially in D1T patients, no systematic review and meta-analysis studies have been conducted on the prevalence of DN in D1T patients in Iran. For this reason, the present study was conducted with the aim of determining the prevalence of DN in patients with D1T in Iran.

Methods: This article is a systematic and meta-analysis review that was conducted from 2000 to 2022 in the articles published in domestic (Iran) and international journals. Congress articles, dissertations, books, and reference sites were not entered into the study. Search keywords include diabetes, type 1 diabetes, D1T, nephropathy, Iran, and children, and adolescents, which were searched in Persian and English. The search was conducted by two members of the research team independently and the outcomes were finally approved by the third person who was considered as the manager of the research team. After data extraction, analysis was done by CMA3 software.

Result: Result showed, the overall prevalence of DN was equal to [confidence interval (CI) = 3.4-26.1] 10%. Figure 3 shows the status of the Funnel plot of the included studies, and in Figures 4 and 5, the relationship between the year of conducting the studies and the sample size with the prevalence of diabetic nephropathy is shown.

Conclusions: Considering the high prevalence of diabetic nephropathy in patients with T1DM, it is suggested that the necessary preventive measures should be taken to reduce the complications of diabetes in these patients.