Document Type : systematic review

Authors

1 Assistant Professor of Internal Medicine, Department of Internal Medicine, School of Medicine, Shahid Mostafa Khomaeini Hospital, Ilam University of Medical sciences, Ilam, Iran

2 Assistant Professor of Pulmonary Diseases, Department of Internal Medicine, School of Medicine, Shahid Mostafa Khomaeini Hospital, Ilam University of Medical sciences, Ilam, Iran

3 Assistant Professor of Neurology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran

Abstract

Background: Urinary tract infections (UTIs) are classified as upper or lower and can be asymptomatic or manifest fever, abdominal pain, sepsis, hematuria, and typical renal colic. Therefore, this study was to determine the prevalence of UTIs in patients with febrile seizure (FS).
Method: The studies published between 2010 and 2022 and indexed in Web of Science (ISI), Scopus, PubMed, EBSCO, SID, and Magiran databases were searched for the purpose of this meta-analysis and systematic review. The study checklist included the author's name, year of publication, location and prevalence of UTI. Prevalence of UTI was analyzed using the RANDOM model after entering the CMA3 software.
Results: Six articles, with the total sample size of 1480 people (778 boys and 702 girls), were selected for the final analysis. They were published between 2011 and 2018; the lowest prevalence rate (11.1%) was reported in a study by Akbar et al., in Golestan city, and the highest prevalence (15.2%) was related to a study by Mahyar et al., in the city of Qazvin. In general, the prevalence of UTI was found to be 3.7 (95% CI: 1.3-10.4), and in boys, 15 (95% CI: 12.2-18.2) in girls with FS; and the overall rate was equal to 9.8 (95% CI: 7.6-12.6).
Conclusions: Considering the overall prevalence of UTIs (9.8%) and its high rate in girls (15%), preventive interventions are suggested.

Keywords

  1. ECDC E. The bacterial challenge: time to react. Stockholm: European Center for Disease Prevention and Control. 2009.
  2. Sula I, Alreshidi MA, Alnasr N, Hassaneen AM, Saquib N. Urinary Tract Infections in the Kingdom of Saudi Arabia, a Review. Microorganisms. 2023; 11(4):952.
  3. McLellan LK, Hunstad DA. Urinary tract infection: pathogenesis and outlook. Trends in molecular medicine. 2016; 22(11):946-57.
  4. Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nature reviews microbiology. 2015; 13(5):269-84.
  5. Linhares I, Raposo T, Rodrigues A, Almeida A. Frequency and antimicrobial resistance patterns of bacteria implicated in community urinary tract infections: a ten-year surveillance study (2000–2009). BMC infectious diseases. 2013; 13:1-14.
  6. Fu AZ, Iglay K, Qiu Y, Engel S, Shankar R, Brodovicz K. Risk characterization for urinary tract infections in subjects with newly diagnosed type 2 diabetes. Journal of Diabetes and its Complications. 2014; 28(6):805-10.
  7. Salari N, Karami MM, Bokaee S, Chaleshgar M, Shohaimi S, Akbari H, Mohammadi M. The prevalence of urinary tract infections in type 2 diabetic patients: a systematic review and meta-analysis. European Journal of Medical Research. 2022; 27(1):20.
  8. Daudon M, Petay M, Vimont S, Deniset A, Tielens F, Haymann J-P, et al. Urinary tract infection inducing stones: Some clinical and chemical data. Comptes Rendus Chimie. 2022; 25(S1):315-34.
  9. Al-Zubaidi OH, Al-Salman AR. Assessment of parents’ awareness about urinary tract infections in children of Babylon Province. Med J Babylon. 2022; 19:50-7.
  10. A‘t Hoen L, Bogaert G, Radmayr C, Dogan HS, Nijman RJ, Quaedackers J, Rawashdeh YF, Silay MS, Tekgul S, Bhatt NR, Stein R. Update of the EAU/ESPU guidelines on urinary tract infections in children. Journal of pediatric urology. 2021; 17(2):200-7.
  11. Coulthard MG, Lambert HJ, Vernon SJ, Hunter EW, Keir MJ, Matthews JN. Does prompt treatment of urinary tract infection in preschool children prevent renal scarring: mixed retrospective and prospective audits? Archives of disease in childhood. 2014; 99(4):342-7.
  12. Tegegne KD, Wagaw GB, Gebeyehu NA, Yirdaw LT, Shewangashaw NE, Kassaw MW. Prevalence of urinary tract infections and risk factors among diabetic patients in Ethiopia, a systematic review and meta-analysis. PloS one. 2023; 18(1):e0278028.
  13. Shokri M, Tarjoman A, Borji M, Solaimanizadeh L. Investigating psychological problems in caregiver of pediatrics with cancer: A systematic review. Journal of Child and Adolescent Psychiatric Nursing. 2020; 33(4):229-38.
  14. Shokri M, Nayyeri S, Salimi N, Nourmohammadi A, Tarjoman A, Borji M, Kalvandi G, Mahdikhani S. Prevalence of Neonatal birth trauma in Iran: a systematic review and meta-analysis. International Journal of Pediatrics. 2021; 9(10):14520-31.
  15. Maleki MM, Afsharloo S, Tarjoman A, Borji M, Mahdikhani S, Shokri M. Prevalence of trauma and related factors in Iranian children and adolescents: systematic review. International Journal of Pediatrics. 2021; 9(9):14293-306.
  16. Gholami A, Hemati R, Khorshidi A, Borji M, Kafashian M, Kalvandi G, Tarjoman A, Mahdikhani S, Shokri M. The prevalence of clinical symptoms in children and adolescents with Covid-19: A systematic review and meta-analysis study. International Journal of Pediatrics-Mashhad. 2020; 8(10):12177-88.
  17. Leung AK, Wong AH, Leung AA, Hon KL. Urinary tract infection in children. Recent patents on inflammation & allergy drug discovery. 2019; 13(1):2-18.
  18. Sánchez JR, Lázaro AMD, Barrientos RR, Cortes JB, Sanz AS, Acuna JB, Cura-González ID. Trends in hospitalization for urinary tract infection in the pediatric age group in the 2000–2015 period in Spain. Anales de Pediatría (English Edition). 2023; 98(3):175-84.
  19. Kaufman J, Temple-Smith M, Sanci L. Urinary tract infections in children: an overview of diagnosis and management. BMJ pediatrics open. 2019; 3(1).
  20. Marco RH, Daza A, Serra JM. Infección urinaria en el niño (1 mes-14 años). Protoc Asoc Española Pediatría. 2008; 1:53-73.
  21. Costea RM, Maniu I, Dobrota L, Pérez-Elvira R, Agudo M, Oltra-Cucarella J, Dragomir A, Bacilă C, Banciu A, Banciu DD, Cipăian CR, Crișan R, Neamtu B. Exploring inflammatory status in febrile seizures associated with urinary tract infections: a two-step cluster approach. Brain Sciences. 2021; 11(9):1168.
  22. Ahmadi A, Shariatmadari F, Yousefichaijan P, Sarmadian R, Dorreh F, Arjmand Shabestari A. Evaluation of Renal Function and Urinalysis in Children with Simple Febrile Convulsions. Clinical Pediatrics. 2022:00099228221142127.
  23. Taheri Z, Rayyani M, Soltanahmadi J, Pouraboli B, Movahedi Z. The effects of febrile convulsion control program on knowledge, attitude, anxiety, and action of mothers. 2014.
  24. Rashwan SM, Ahmed YAE-R, Ibrahim AK, Kasem IAE-R. Association between iron-deficiency anemia and febrile convulsion in children. Al-Azhar Assiut Medical Journal. 2022; 20(1):8.
  25. Akbar Momen A, Mehdi Monajemzadeh S, Gholamian M. The frequency of urinary tract infection among children with febrile convulsion. Iranian Journal of Child Neurology. 2011; 5(3):29-32.
  26. Mahyar A, Ayazi P, Azimi E, Dalirani R, Barikani A, Esmaeily S. The relation between urinary tract infection and febrile seizure. Iranian journal of child neurology. 2018; 12(4):120.
  27. Kazeminezhad B, Taghinejad H, Borji M, Seymohammadi R. Evaluation of the prevalence of urinary tract infection in children with febrile seizure. Journal of Comprehensive Pediatrics. 2018; 9(3).
  28. Abedi A, Ashrafi M, Moghtaderi M. Prevalence of urinary tract infection among children with febrile convulsion. Int J Nephrol Kidney Fail. 2017; 3(10):16966.
  29. Esmaeili M, Ghane F, Asadi N. Frequency of urinary tract infection in children with febrile convulsion. Medical Journal of Mashhad University of Medical Sciences. 2015; 58(2):106-11.
  30. Moghaddam KB, Bidabadi E, Rad AH, Dalili S. Causes of infectious diseases which tend to get into febrile convulsion. International Journal of Infection. 2016; 3(1).
  31. Hossain A, Hossain SA, Fatema AN, Wahab A, Alam MM, Islam MN, Hossain MZ, Ahsana GU. Age and gender-specific antibiotic resistance patterns among Bangladeshi patients with urinary tract infection caused by Escherichia coli. Heliyon. 2020; 6(6):e04161.
  32. Mahmoudi H, Emadmomtaz H, Karimitabar Z, Emam AH, Alikhani MY. Prevalence of asymptomatic urinary tract infection in primary school children of Hamadan City and drug resistance of isolated microorganisms in 2014. Pajouhan Scientific Journal. 2015; 13(3):8-14.
  33. Ali HH, AL-Dujaili ANG. Comparison of Some Parameters in Patients Infected with Urinary Tract Infection According to Age and Gender in Al-Najaf Governorate. Egyptian Journal of Chemistry. 2022; 65(11):447-53.
  34. Rostami, Magsodian, Arian Pour, Arian. Prevalence of Asymptomatic Urinary Tract Infection in Primary School Children of Ardabil. Journal of Ardabil University of Medical Sciences. 2005; 5(3):241-5.
  35. Van Batavia JP, Ahn JJ, Fast AM, Combs AJ, Glassberg KI. Prevalence of urinary tract infection and vesicoureteral reflux in children with lower urinary tract dysfunction. The Journal of urology. 2013; 190(4S):1495-500.
  36. Kantamalee W, Katanyuwong K, Louthrenoo O. Clinical characteristics of febrile seizures and risk factors of its recurrence in Chiang Mai University Hospital. Neurol Asia. 2017; 22(3):203-8.
  37. Yao Y, Zhao L, Zhou H, Ge T, Zhang L, Liu Y, et al. Inflammatory Indicators and Pathogenic Bacteria of Urinary Tract Infections with Convulsion in Children. Chinese General Practice. 2021; 24(29):3711.
  38. Naseri M, Bakhtiari E, Tafazoli N. An observational epidemiological study of febrile convulsion due to urinary tract infection. Journal of Nephropathology. 2020; 9(2).