Document Type : original article


1 Department of Environmental Health Engineering, Faculty of Health, Yasuj. University of Medical Sciences, Yasuj, Iran

2 Social Determinants of Health Research Center Yasuj University of Medical Sciences, Yasuj, Iran.

3 Department of public health ,Health and Nutrition Faculty ,Lorestan university of science

4 Department of Environmental Health Engineering, Faculty of Health, Yasuj. University of Medical Sciences, Yasuj, Iran.


Background: Non-standard creativity tools and entertainment products may contain heavy metals. Children are more sensitive than adults to this potentially toxic chemicals. This study aimed at investigating harmful elements in children’s products in Iran.
Methods: In this descriptive-analytical study, Iranian samples (13 play dough samples, 6 finger paint, and 1 face paint sample) and 10 imported samples were investigated by atomic absorption spectrophotometry. The statistical analyses were performed using the SPSS statistical package (version 19).
Results: The results of this study showed that the lead content of 2 samples of play dough (76%), 10 samples of finger paint (100%) and 3 samples of face paint (100%) was higher than the permissible limits set by the Iranian National Standards Organization. Lead and cadmium contents of 100% of the samples of play dough, along with the face and finger paints exceeded the permissible limits set by the European Union.
Conclusion: Research on prolonged exposure to harmful elements and comprehensive risk characterization for toys is recommended.


  1. Jadi A. Improving the communication for children with speech disorder using the smart toys. arXiv preprint arXiv:190604251. 2019.
  2. Eliot L. Impact of gender-typed toys on children’s neurological development. 2018.
  3. Landrigan PJ, Fuller R, Fisher S, Suk WA, Sly P, Chiles TC, Bose-O'Reilly S. Pollution and children's health. Science of the Total Environment. 2019; 650:2389-94.
  4. Zhou Y, Ma W. Heavy Metal Exposure and Children’s Health. Emerging Chemicals and Human Health: Springer; 2019. p. 79-97.
  5. Bellinger DC. Environmental Chemical Exposures and Intellectual Disability in Children. Handbook of Intellectual Disabilities: Springer; 2019. p. 347-63.
  6. Ledwaba SE, Becker P, Traore-Hoffman A, Potgieter N. Bacterial Contamination of Children’s Toys in Rural Day Care Centres and Households in South Africa. International journal of environmental research and public health. 2019; 16(16):2900.
  7. Greenway JA, Gerstenberger S. An evaluation of lead contamination in plastic toys collected from day care centers in the Las Vegas Valley, Nevada, USA. Bulletin of environmental contamination and toxicology. 2010; 85(4):363-6.
  8. Ismail SNS, Mohamad NS, Karuppiah K, Abidin EZ, Rasdi I, Praveena SM. Heavy metals content in low-priced toys. JEAS. 2017; 5:1499-509.
  9. Njati SY, Maguta MM. Lead-based paints and children's PVC toys are potential sources of domestic lead poisoning–A review. Environmental pollution. 2019; 249:1091-105.
  10. Apanpa-Qasim AF, Adeyi AA, Mudliar SN, Raghunathan K, Thawale P. Examination of lead and cadmium in water-based paints marketed in Nigeria. Journal of Health and Pollution. 2016; 6(12):43-9.
  11. Bhutto S, Jalbani N, Shareef A, Tahir M, Begum R, Ahmed F, et al. Evaluation of Toxic and Essential Metals in Some Selected Chewing Food Products and their Daily Intake by the Population of Karachi, Pakistan. Mediterranean Journal of Chemistry. 2018; 6(6):223-30.
  12. Mudgal V, Madaan N, Mudgal A, Singh R, Mishra S. Effect of toxic metals on human health. The Open Nutraceuticals Journal. 2010; 3(1).
  13. Ali I, AL-Hammadi SA, Saleh TA. Simultaneous sorption of dyes and toxic metals from waters using synthesized titania-incorporated polyamide. Journal of Molecular Liquids. 2018; 269:564-71.
  14. Al-Qutob M, Asafra A, Nashashibi T, Qutob AA. Determination of different trace heavy metals in children’s plastic toys imported to the West Bank/Palestine by ICP/MS-environmental and health aspects. Journal of Environmental Protection. 2014; 5(12):1104.
  15. Guney M, Zagury GJ. Bioaccessibility of As, Cd, Cu, Ni, Pb, and Sb in toys and low-cost jewelry. Environmental science & technology. 2014; 48(2):1238-46.
  16. Guney M, Zagury GJ. Children's exposure to harmful elements in toys and low-cost jewelry: characterizing risks and developing a comprehensive approach. Journal of Hazardous Materials. 2014; 271:321-30.
  17. Korfali SI, Sabra R, Jurdi M, Taleb RI. Assessment of toxic metals and phthalates in children’s toys and clays. Archives of environmental contamination and toxicology. 2013; 65(3):368-81.
  18. Fang Y, Sun X, Yang W, Ma N, Xin Z, Fu J, Liu X, Liu M, Mariga AM, Zhu X, Hu Q. Concentrations and health risks of lead, cadmium, arsenic, and mercury in rice and edible mushrooms in China. Food Chemistry. 2014; 147:147-51.
  19. Kohzadi S, Shahmoradi B, Ghaderi E, Loqmani H, Maleki A. Concentration, source, and potential human health risk of heavy metals in the commonly consumed medicinal plants. Biological trace element research. 2019; 187(1):41-50.
  20. Lee M-J, Chou M-C, Chou W-J, Huang C-W, Kuo H-C, Lee S-Y, Wang LJ. Heavy metals’ effect on susceptibility to attention-deficit/hyperactivity disorder: implication of lead, cadmium, and antimony. International journal of environmental research and public health. 2018; 15(6):1221.
  21. Carocci A, Catalano A, Lauria G, Sinicropi MS, Genchi G. Lead Toxicity, Antioxidant Defense. 2015.
  22. Alijagic A, Islamagic E, Focak M, Suljevic D. Effects of trivalent and hexavalent dietary chromium on blood biochemical profile in Japanese quails. Bulgarian Journal of Veterinary Medicine. 2018; 21(4).
  23. Mishra S, Bharagava RN. Toxic and genotoxic effects of hexavalent chromium in the environment and its bioremediation strategies. Journal of Environmental Science and Health, Part C. 2016; 34(1):1-32.
  24. Ray RR. Adverse hematological effects of hexavalent chromium: an overview. Interdisciplinary toxicology. 2016; 9(2):55-65.
  25. Zhou Q, Xi S. A review on arsenic carcinogenesis: Epidemiology, metabolism, genotoxicity and epigenetic changes. Regulatory Toxicology and Pharmacology. 2018; 99:78-88.
  26. Sodhi KK, Kumar M, Agrawal PK, Singh DK. Perspectives on arsenic toxicity, carcinogenicity and its systemic remediation strategies. Environmental Technology & Innovation. 2019; 16:100462.
  27. Ganesan N, Bambino K, Boffetta P, Labgaa I. Exploring the potential carcinogenic role of arsenic in gallbladder cancer. European Journal of Cancer Prevention. 2020; 29(2):100-9.
  28. Gamboa-Loira B, Cebrian ME, Franco-Marina F, Lopez-Carrillo L. Arsenic metabolism and cancer risk: a meta-analysis. Environmental research. 2017; 156:551-8.
  29. Wei S, Zhang H, Tao S. A review of arsenic exposure and lung cancer. Toxicology research. 2019; 8(3):319-27.
  30. Chakraborti D, Rahman MM, Das B, Chatterjee A, Das D, Nayak B, Pal A, Chowdhury U, Ahmed S, Biswas BK, Sengupta M, Hossain A, Samanta G, Roy MM, Dutta RN, Saha KC, Mukherjee SC, Pati S, Kar PB, Ukherjee A, Kumar M. Groundwater arsenic contamination and its health effects in India. Hydrogeology Journal. 2017; 25(4):1165-81.
  31. Liu C, Hystad G, Golden JJ, Hummer DR, Downs RT, Morrison SM, Ralph JP, Hazen RM. Chromium mineral ecology. American Mineralogist. 2017; 102(3):612-9.
  32. Hayat MT, Nauman M, Nazir N, Ali S, Bangash N. Environmental hazards of cadmium: past, present, and future. Cadmium Toxicity and Tolerance in Plants: Elsevier; 2019. p. 163-83.
  33. Teklay A. Physiological effect of chromium exposure: A review. Int J Food Sci Nutr Diet S. 2016; 7: 1-11.
  34. Tao Y, editor Progress in chromium research and related diseases. AIP Conference Proceedings; 2019: AIP Publishing LLC.
  35. Erbas Z, Karatepe A, Soylak M. Heavy metal contents of play dough, face and finger paint samples sold in Turkish markets. Talanta. 2017; 170:377-83.
  36. Gibb HJ, Lees PS, Pinsky PF, Rooney BC. Lung cancer among workers in chromium chemical production. American journal of industrial medicine. 2000; 38(2):115-26.
  37. Dehghani M, Mosaferi F. Determination of Heavy Metals (Cadmium, Arsenic and Lead) in Iranian, Pakistani and Indian rice Consumed in Hormozgan Province, Iran. Journal of Mazandaran University of Medical Sciences. 2016; 25(134):363-7.
  38. Association of Official Analytical Chemists International (AOAC). Official Methods of Analysis. 17th ed. AOAC UG.
  39. Union E. EN14332 - Foodstuffs - Determination of trace elements –55-Determination of arsenic in seafood by graphite furnace atomic absorption spectrometry GFAAS) after microwave digestion.
  40. Ardakani S BB DoH MCiC sTMiH CiJoRi EH-.
  41. Palad F BK, Afshari R. Is play-dough a vector for transporting and accumulating lead? A pilot study of daycares in greater Vancouver. Asia Pacific Journal of Medical Toxicology; 5(3):72-4.
  42. Yazdanfar N, Vakili Saatloo N, Sadighara P. Contamination of potentially toxic metals in children’s toys marketed in Iran. Environmental Science and Pollution Research. 2022; 29(45):68441-6.
  43. Pourmoghaddas H PA, Kavehzadeh F. Percentage of toxic trace elements Pb, Cr and Cd in certain plastic toys, Isfahan City. SSU_Journals.14 (1):59-64.
  44. Murphy T, Lim S, Kim S, Irvine K, Chaiwat W, Wilson K. Metal contamination in low-cost jewelry and toys in Cambodia. Journal of Health and Pollution. 2016; 6(11):47-57.
  45. Loureiro S, Santos C, Pinto G, Costa A, Monteiro M, Nogueira AJ, Soares AMVM. Toxicity assessment of two soils from Jales mine (Portugal) using plants: Growth and biochemical parameters. Archives of Environmental Contamination and Toxicology. 2006; 50:182-90.
  46. Shukla V, Shukla P, Tiwari A. Lead poisoning. Indian Journal of Medical Specialities. 2018; 9(3):146-9.
  47. Ettinger AS, Leonard ML, Mason J. CDC’s lead poisoning prevention program: a long-standing responsibility and commitment to protect children from lead exposure. Journal of public health management and practice: JPHMP. 2019; 25(Suppl 1 LEAD POISONING PREVENTION):S5.
  48. Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ. Heavy metal toxicity and the environment. Molecular, clinical and environmental toxicology: volume 3: environmental toxicology. 2012:133-64.
  49. Horton LM, Mortensen ME, Iossifova Y, Wald MM, Burgess P. What do we know of childhood exposures to metals (arsenic, cadmium, lead, and mercury) in emerging market countries? International Journal of Pediatrics. 2013; 2013.
  50. Sindiku O, Osibanjo O. Some priority heavy metals in children toy’s imported to Nigeria. J Toxicol Environ Health Sci [Internet]. 2011; 3(4):109-15.