Document Type : original article
Authors
- BEHZAD GHAZANFARI 1
- Alireza Ahmadi 2
- Mohammad Reza Sabri 2
- medi ghaderian 3
- Bahar Dehghan 2
- Chehreh Mahdavi 2
- Davood Ramezaninezhad 2
- Zahra Pourmoghaddas 2
- Mohammad Reza Maracy 4
- Pejman Nemat Gorgani 5
1 Behzad Ghazanfari, Pediatric Cardiology Fellow, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
2 Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
3 Pediatrics Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan,Iran
5 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Introduction: Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but severe condition that can develop in children who have had COVID-19. It can lead to cardiovascular complications, possibly caused by endothelial dysfunction and arterial stiffness.
Methods: This study aimed to investigate the cardiovascular health of children with MIS-C compared to healthy controls. Fifty-nine children with MIS-C and Fifty-nine healthy controls were included in this cohort study. Non-invasive techniques were used to measure the brachial artery's flow-mediated dilation (FMD), aortic distensibility (AD), and aortic strain (AS).
Results: The MIS-C group had significantly higher systolic blood pressure (P= 0.012) and pulse pressure (P= 0.046) than the control group. FMD, AS, and AD were lower in the MIS-C group but with no significant differences.
Conclusion: Children suffering from MIS-C have exhibited higher pulse pressure, which indicates that they may have potential arterial stiffness. They also had lower FMD, which suggests endothelial dysfunction. FMD is a more reliable indicator of endothelial dysfunction in MIS-C patients than aortic strain. These findings highlight the significance of early assessment and monitoring of cardiovascular complications in MIS-C patients. Endothelial dysfunction and arterial stiffness are known risk factors for future cardiovascular events.
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