1 Department of Pediatrics Gastroenterology, Faculty of Medicine,Mashhad University of Medical Sciences, Mashhad, Iran.

2 Department of Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Department of Pediatrics, North Khorasan University of Medical Sciences, Bojnurd, Iran.

4 General Physician, Mashhad University of Medical Sciences, Mashhad, Iran.


Gastrointestinal Endoscopy is  as a diagnosis and treatment of gastrointestinal diseases in children. Due to severe response and spastic in  the muscles of the digestive tract is created during endoscopy,endoscopy is often face with difficult. The aim of this study is to evaluate peppermint impact in pyloric spasm in children undergo endoscopy.
Material and Methods:
In this clinical trial study, 120 children (under 14 years old) in Ghaem hospital that Pyloric spasm during endoscopy were randomly divided into two groups, peppermint (n=60) and control (n=60) respectively. Case group recieve peppermint and control group receive placebo. Data were analyzed using SPSS version 11.5 and descriptive and analytical tests    (T-test, Corraletion, Mann-Whitney).
Pyloric sphincter stayed open in 48.3% of peppermint   group patients and 5% of controlgroup (P<0.000). The mean time to endoscopy in peppermintgroup (9/301+0/351) and control group was (10/149+0/337) and this difference was significant. Pyloric spasm in peppermint groupduration less than 60 seconds and in control group at 60% of them, more than 60 seconds.
Peppermint could reduce endoscopy duration in children and increase endoscopic team satisfaction and decrease pyloric spasm.
Key words: Pyloric spasm, Endoscopy, Peppermint