1 Dental Research Center, Department of Oral & Maxillofacial Pathology, Faculty of Dentistry, Zahedan University of Medical Science, Zahedan, Iran.

2 Dental Research Center, Department of Oral & Maxillofacial Pathology, Faculty of Dentistry, Zahedan University of Medical Science, Zahedan, Iran.

3 Dental Research Center, Department of Pediatric dentistry, Faculty of Dentistry, Zahedan University of Medical Science, Zahedan, Iran.

4 Zahedan University of Medical Science, Zahedan, Iran.


The frequency of pediatric and adolescent oral and maxillofacial lesions is various in different societies. The present study aimed at investigating the frequency of oral and maxillofacial pediatric and adolescent biopsies in Zahedan (southeast Iran), and compare the results with other epidemiologic studies.
Methods and Materials
This retrospective study reviewed oral and maxillofacial lesions in patients with 0-18 years old referring to the treatment centers of Zahedan University of Medical Sciences during 12-years period. Patients’ demographic information including age, gender and location of the lesion were collected and statistically analyzed.
In general, among 1112 oral and maxillofacial lesions, 154 (13.9%) cases were related to children and adolescents younger than 18 years old. The average age of patients was 11.4 ± 4.9, 53.2% and 46.8% of them were boys and girls, respectively. The most frequent sites of lesions were the gingiva and lip. The most prevalent lesions included inflammatory/reactive, cystic and neoplastic lesions, respectively. Benign and malignant tumors comprised 12.3% and 4.5% of cases. Moreover, pyogenic granuloma and peripheral giant cell granuloma (PGCG) were the most frequent lesions.
The most prevalent oral and maxillofacial lesions in patients under 18 years old were inflammatory/reactive lesions in gingiva and in the 13-18 age range. Determining the characteristics of these lesions in the children and adolescents population provides a firm groundwork for proper diagnosis and treatment.


1.         Furlanetto DL, Crighton A, Topping GV. Differences in methodologies of measuring the prevalence of oral mucosal lesions in children and adolescents. Int J Paediatr Dent. 2006;16(1):31-9.
2.         Jones AV, Franklin CD. An analysis of oral and maxillofacial pathology found in adults over a 30-year period. J Oral Pathol Med. 2006;35(7):392-401.
3.         Bodner L. Cystic lesions of the jaws in children. Int J Pediatr Otorhinolaryngol. 2002;62(1):25-9.
4.         Servato JP, de Souza PE, Horta MC, Ribeiro DC, de Aguiar MC, de Faria PR, et al. Odontogenic tumours in children and adolescents: a collaborative study of 431 cases. Int J Oral Maxillofac Surg. 2012;41(6):768-73.
5.         Ajayi OF, Adeyemo WL, Ladeinde AL, Ogunlewe MO, Omitola OG, Effiom OA, et al. Malignant orofacial neoplasms in children and adolescents: a clinicopathologic review of cases in a Nigerian tertiary hospital. Int J Pediatr Otorhinolaryngol. 2007;71(6):959-63.
6.         Fang QG, Shi S, Li ZN, Zhang X, Liu FY, Sun CF. Epithelial salivary gland tumors in children: a twenty-five-year experience of 122 patients. Int J Pediatr Otorhinolaryngol. 2013;77(8):1252-4.
7.         Chen YK, Lin LM, Huang HC, Lin CC, Yan YH. A retrospective study of oral and maxillofacial biopsy lesions in a pediatric population from southern Taiwan. Pediatr Dent. 1998;20(7):404-10.
8.         Dhanuthai K, Banrai M, Limpanaputtajak S. A retrospective study of paediatric oral lesions from Thailand. Int J Paediatr Dent. 2007;17(4):248-53.
9.         Wang YL, Chang HH, Chang JY, Huang GF, Guo MK. Retrospective survey of biopsied oral lesions in pediatric patients. J Formos Med Assoc. 2009;108(11):862-71.
10.       Al Yamani AO, Al Sebaei MO, Bassyoni LJ, Badghaish AJ, Shawly HH. Variation of pediatric and adolescents head and neck pathology in the city of Jeddah: A retrospective analysis over 10 years. Saudi Dent J. 2011;23(4):197-200.
11.       Siadati S, Seyedmajidi M, Sharbatdaran M. Frequency of different oral lesions in children and adolescents in Babol, Northern Iran. Caspian J Intern Med. 2013;4(4):773-6.
12.       Lima Gda S, Fontes ST, de Araujo LM, Etges A, Tarquinio SB, Gomes AP. A survey of oral and maxillofacial biopsies in children: a single-center retrospective study of 20 years in Pelotas-Brazil. J Appl Oral Sci. 2008;16(6):397-402.
13.       Zuniga MD, Mendez CR, Kauterich RR, Paniagua DC. Paediatric oral pathology in a Chilean population: a 15-year review. Int J Paediatr Dent. 2013;23(5):346-51.
14.       Lawoyin JO. Paediatric oral surgical pathology service in an African population group: a 10 year review. Odontostomatol Trop. 2000;23(89):27-30.
15.       Mouchrek MMM, Gonçalves LM, Bezerra-Júnior JRS, Maia EdCS, Silva RAd, Cruz MCF. Oral and maxillofacial biopsied lesions in Brazilian pediatric patients: a 16-year retrospective study. Revista Odonto Ciência. 2011;26(3):222-6.
16.       Vale EB, Ramos-Perez FM, Rodrigues GL, Carvalho EJ, Castro JF, Perez DE. A review of oral biopsies in children and adolescents: A clinicopathological study of a case series. J Clin Exp Dent. 2013;5(3):e144-9.
17.       Krishnan R, Ramesh M, Paul G. Retrospective evaluation of pediatric oral biopsies from a dental and maxillofacial surgery centre in salem, Tamil Nadu, India. J Clin Diagn Res. 2014;8(1):221-3.
18.       Kamulegeya A, Lakor F. Oral maxillofacial tumors and tumor-like conditions: a Ugandan survey. Pediatric surgery international. 2011;27(9):925-30.
19.       Shah SK, Le MC, Carpenter WM. Retrospective review of pediatric oral lesions from a dental school biopsy service. Pediatr Dent. 2009;31(1):14-9.
20.       Sousa FB, Etges A, Correa L, Mesquita RA, de Araujo NS. Pediatric oral lesions: a 15-year review from Sao Paulo, Brazil. J Clin Pediatr Dent. 2002;26(4):413-8.
21.       Gultelkin SE, Tokman B, Turkseven MR. A review of paediatric oral biopsies in Turkey. Int Dent J. 2003;53(1):26-32.
22.       Jafarzadeh H, Sanatkhani M, Mohtasham N. Oral pyogenic granuloma: a review. J Oral Sci. 2006;48(4):167-75.
23.       Urs AB, Arora S, Singh H. Intra-osseous jaw lesions in paediatric patients: a retrospective study. J Clin Diagn Res. 2014;8(3):216-20.
24.       Zhang LL, Yang R, Zhang L, Li W, MacDonald-Jankowski D, Poh CF. Dentigerous cyst: a retrospective clinicopathological analysis of 2082 dentigerous cysts in British Columbia, Canada. Int J Oral Maxillofac Surg. 2010;39(9):878-82.
25.       Al-Khateeb T, Al-Hadi Hamasha A, Almasri NM. Oral and maxillofacial tumours in north Jordanian children and adolescents: a retrospective analysis over 10 years. Int J Oral Maxillofac Surg. 2003;32(1):78-83.
26.       Aregbesola SB, Ugboko VI, Akinwande JA, Arole GF, Fagade OO. Orofacial tumours in suburban Nigerian children and adolescents. Br J Oral Maxillofac Surg. 2005;43(3):226-31.
27.       Elarbi M, El-Gehani R, Subhashraj K, Orafi M. Orofacial tumors in Libyan children and adolescents. A descriptive study of 213 cases. Int J Pediatr Otorhinolaryngol. 2009;73(2):237-42.
28.       Jaafari-Ashkavandi Z, Ashraf MJ. A clinico-pathologic study of 142 orofacial tumors in children and adolescents in southern iran. Iran J Pediatr. 2011;21(3):367-72.
29.       Tanaka N, Murata A, Yamaguchi A, Kohama G. Clinical features and management of oral and maxillofacial tumors in children. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88(1):11-5.
30.       Adebayo ET, Ajike SO, Adekeye EO. Tumours and tumour-like lesions of the oral and perioral structures of Nigerian children. Int J Oral Maxillofac Surg. 2001;30(3):205-8.
31.       Trobs RB, Mader E, Friedrich T, Bennek J. Oral tumors and tumor-like lesions in infants and children. Pediatr Surg Int. 2003;19(9-10):639-45.
32.       Tanrikulu R, Erol B, Haspolat K. Tumors of the maxillofacial region in children: retrospective analysis and long-term follow-up outcomes of 90 patients. Turk J Pediatr. 2004;46(1):60-6.
33.       Iatrou I, Theologie-Lygidakis N, Tzerbos F, Schoinohoriti OK. Oro-facial tumours and tumour-like lesions in Greek children and adolescents: an 11-year retrospective study. J Craniomaxillofac Surg. 2013;41(5):437-43.
34.       Kalyanyama BM, Matee MI, Vuhahula E. Oral tumours in Tanzanian children based on biopsy materials examined over a 15-year period from 1982 to 1997. Int Dent J. 2002;52(1):10-4.
35.       Albright JT, Topham AK, Reilly JS. Pediatric head and neck malignancies: US incidence and trends over 2 decades. Arch Otolaryngol Head Neck Surg. 2002;128(6):655-9.
36.       Chow CW, Tabrizi SN, Tiedemann K, Waters KD. Squamous cell carcinomas in children and young adults: a new wave of a very rare tumor? J Pediatr Surg. 2007;42(12):2035-9.