1 Autism Center of Noor Hedayar Mashhad, Mashhad, Iran.

2 Department of Biomedical Engineering, International University of Imam Reza (AS), Mashhad, Iran.

3 Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


The goal of research is investigation on the effectiveness of Holistic Multi-dimensional Treatment Model (HMTM) in improvement of CARS test indicators in children with Autism Spectrum Disorder (ASD) and it is done without pharmaceutical interventions, without names and accompanied by parental satisfaction questionnaire.
Materials and Methods
In this study with purposeful sampling method, 60 autistic children chosen randomly among 6-10 year-old patients were taken under a 12-month observation. At the beginning of this research they were taken the CARS pre-test and then in each month a complete behavioral HMTM checklist and a CARS test was taken. Observing HMTM treatment model, includes intuitive checklist with the aim of intuitive adjustment, abnormal behaviors’ checklist with the aim of decreasing them, individual behaviors’ checklist with the aim of increasing them and emotional interactive behaviors checklist with the aim of improvement that are conducted in statistical tables.
Results shown a positive impact of HMTM in treatment trend of autism spectrum disorder considering sum of CARS points, also the effect on each CARS test parameters and CARS parameters improvements are meaningful holistic approach in HMTM method has interpreted some vague CARS parameters furthermore (P<0.05).
The statistical properties of CARS test with HMTM treatment model, indicates a high correlation coefficient and a significant relationship there was in behavior tables of HMTM and CARS test.
Holistic multi-dimensional treatment modelhas caused considerable and improvement children’s individual interactions and intuitive balance.


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