1 Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

2 School of Nursing and Midwifery, Zahedan University of Medical Sciences, Zahedan, Iran

3 Department of Maxillofacial Surgery, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran. 5Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.


Oral cleft is the most common orofacial congenital anomaly among live births. This anomaly at birth is one of the main causes of children disability and mortality.  Congenital heart disease (CHD) is one of the most common anomalies in oral clefts.  This study aimed to assess the incidence of congenital heart diseases anomalies in newborns with oral clefts.
Materials and Methods
This study performed on 48,692 live born to estimate incidence of oral clefts from 1
December 2013 to 31
November 2015 from three general hospitals in Zahedan, The capital city of the Sistan & Baluchestan  province, Iran. All oral cleft patients were under echocardiography to diagnosis the incidence of CHD as associated anomaly. The collected data were processed using SPSS-16.
The results of the analysis showed that the incidence of cleft lip was higher in boys than girls, while the cleft palate was higher in girls. Lip/palate cleft was higher for boys.  Oral clefts patients accounted of 102 (0.2%) with incidence rate of 2.095 per 1000 lives. Of 102 patients 19 (18.62%), 39(35.24%) and 44(43.14%) were oral lip, oral palate and both respectively. The incidence of CHD in patients with oral clefts was 26.5%, while the incidences for cleft lip, cleft palate and both were 15.79%, 20.51%, and 36.36% respectively.
From the study concluded that the rate of CHD among children with oral clefts was high compared with the healthy children.  Strongly is suggested the echocardiography for these patients to have early diagnostic of CHD to manage any life-threatening.