International Journal of Pediatrics

Advanced tissue engineering in periodontal Regeneration

Seyed Ali Banihashemrad

Volume 2, Issue 2.3 , May 2014, , Pages 54-54

https://doi.org/10.22038/ijp.2014.2717

Abstract

The old wishes of people were to regenerate lost tissues of periodontium that this fact is achieved by gen and cell therapy .Periodontal disease is a chronic inflammation around the ... Read More

Gluten - Not a Friendly Protein

E Tafreshi; A Jafarzade Noghani; B Khairkhah; M Yazdani; S Seddighi; S khayam

Volume 2, Issue 2.1 , April 2014, , Pages 54-54

https://doi.org/10.22038/ijp.2014.2514

Abstract

Introduction: Gluten is a protein found in grains. Research has shown that the gluten that is in grains of wheat, barley, rye, and oats (to a lesser degree) is toxic to many ... Read More Introduction: Gluten is a protein found in grains. Research has shown that the gluten that is in grains of wheat, barley, rye, and oats (to a lesser degree) is toxic to many individuals. While gluten is essential for the make-up of these 4 grains, our bodies do not need it. Is it healthful? The protein in today’s wheat is poorly digested and can be harmful. An estimated 95% of prepared foods on the grocery shelves contain the toxic forms of gluten. Non-Celiac Gluten Sensitivity: When Gluten Gets into Our Bloodstream Non-Celiac Gluten Sensitivity is an immune response to gluten that can happen to anyone. This type of response is not inherited like Celiac Disease. Rather, it involves a normal response to the abnormal appearance of gluten in the body. Health problems result from eating too much gluten in the diet (overload) and/ or the development of a common condition called “Leaky Gut Syndrome.” Mild problems include fatigue and anxiety. However, if the overload of gluten or the intestinal “leakiness” is prolonged, gluten can wreak havoc with consequences like migraine, arthritis, and ADHD. Celiac Disease: When Gluten Harms Our Digestive Tract Celiac Disease is an inherited susceptibility to physical and mental harm from eating gluten. Once triggered, an auto-immune response causes inflammation and damage to vital tissues lining the small intestine, which in turn, results in failure to absorb nutrients in food. Various degrees of damage may occur at any time and at any age. In the majority of people born with the susceptibility, there are few telltale signs, so that most of us are not aware that we carry this genetic capability to make auto-immune antibodies. Left untreated, active Celiac Disease can lead to serious health consequences. Making the connection to Celiac Disease may be difficult, unless there are classic problems like abdominal bloating, pain, heartburn, or diarrhea. Symptom Guide: Manifestations of Gluten Damage to Our Bodies This section details the many different and seemingly unrelated effects that can be caused by gluten damage. The GlutenFreeWorks Symptom Guide identifies manifestations in an easy to access format. Testing for Celiac Disease and Gluten Sensitive Disorders Diagnosis starts with a high degree of suspicion, meaning the doctor needs to look for symptoms based on an accurate health history and a complete physical examination. Testing begins with bloodwork looking for the presence of 1) auto-immune antibodies that are produced against our own cells because of gluten and 2) specific antibodies that are directed against gluten itself. Treatment: The essential treatment for Celiac Disease and other gluten sensitive disorders is a gluten-free diet. More than this, here you can learn the following six key elements for better management as advanced by the National Institutes for Health: Consultation with a skilled dietitian Education about celiac disease Lifelong adherence to a gluten-free diet Identification and treatment of nutritional deficiencies and other manifestations Access to an advocacy group Continuous long-term follow-up by a multidisciplinary team

Effect of Platelets Rich Plasma on Skin Rejuvenation

Mahnaz Banihashemi; Daryoush Hamidi Alamdaran; Solmaz Nakhaeizadeh

Volume 2, Issue 2.3 , May 2014, , Pages 55-55

https://doi.org/10.22038/ijp.2014.2718

Abstract

Introduction Autologous plasma-rich platelet (PRP) is a human platelet concentrated product which is in low volume of plasma. Using PRP in rejuvenation and resolution of some cosmetic ... Read More Introduction Autologous plasma-rich platelet (PRP) is a human platelet concentrated product which is in low volume of plasma. Using PRP in rejuvenation and resolution of some cosmetic problems has been already popular in many countries and also in Iran. As no study performed in this field in Iran and regarding the high prevalence of using PRP in society with no validate references in the case of skin rejuvenation, we are trying to research clinical effects of PRP facial rejuvenation. Materials and Methods: In this clinical trial, 30 volunteer persons with Glogau score of II and III were participated. Appropriate amount of blood obtained in two sessions with 3 months interval and used in order to produce plasma-rich platelet. Immediately after production of platelets, platelet concentrated product injected in sterile condition and 4 ˚C by an expert physician. Injections were 1 cc in upper zone of face, 1 cc in cheeks and 1cc in lower zone of face and were sub-dermal and intra-dermal (Threading technique). Injections were done in two sessions with 3 months interval. Before the beginning and after the end of treatment, digital photography of patients provided. Evaluation of wrinkle improvement was done on the basis of personal judgment of patient and observation of before and after treatment photography by therapeutic physician and a dermatologist who is unaware of order of photos. Results: Mean age of patients was 45.1±6.89 years and in the range of 35 to 55 years. In 3 and 6 months follow-ups, most of patients reported moderate to excellent improvement in periorbital darkness, periorbital wrinkle, nasolabial fold and skin rigidity. Also, in general evaluation of patients in 3 and 6 months follow-ups, most of the patients reported moderate to excellent improvement and only 17% of patients reported no improvement or mild improvement. In therapeutic physician assessment, in 3 and 6 months follow-ups, mild to moderate improvement in periorbital wrinkle and dyschromia in most of the patients reported. But in nasolabial fold assessment, no improvement reported in most of them. In second physician assessment, no improvement or mild improvement was observed in periorbital wrinkle in 3 and 6 months follow-ups. For dyschromia, mild to moderate improvement and for nasolabial fold, no improvement were reported in most of the patients. Conclusion: In this study, patients’ improvement in the assessments of the patients, therapeutic physician and second physician (unaware of study) observed variably which was the most in patients’ satisfaction evaluation. Additionally, best effects of PRP in rejuvenation were specified to improvement of periorbital darkness and decreasing skin wrinkle. Keywords: Facial skin rejuvenation, Plasma-rich platelet.

The Effects of Zinc Sulfate on Sepsis Outcomes in Neonates: A Blind Clinical Trial

Roya Choopani; Nabiollah Asadpour; Majid Hamidi; Marzieh Khalili; Negin Ebrahimi; Sheida Choopani

Volume 9, Issue 9 , September 2021, , Pages 14474-14480

https://doi.org/10.22038/ijp.2021.54568.4313

Abstract

Background: The present study aimed at assessing the effects of zinc sulfate supplementation on sepsis outcomes in neonates. Methods: This randomized double-blind clinical trial was ... Read More

Complementary and Alternative Medicine (CAM) Use in Pediatric Diseases: A Short Review

MR Noras; M Yousefi; MA Kiani

Volume 2, Issue 2.1 , April 2014, , Pages 55-55

https://doi.org/10.22038/ijp.2014.2515

Abstract

CAM (Complementary and Alternative Medicine) therapies have become increasingly popular in pediatric populations. phytotherapy are the most common CAM used in children. Yet, little ... Read More

Co-Transplantation of VEGF-Expressing Human Embryonic Stem Cell Derived Mesenchymal Stem Cells to Enhance Islet Revascularization in Diabetic Nude Mice

Ensiyeh Hajizadeh; Yaser Tahamtani; Mohammad Ali Shokrgozar; Harry Heimberg; Yves Heremans; Philippe Ravassard; Hossein Baharvand

Volume 2, Issue 2.3 , May 2014, , Pages 56-56

https://doi.org/10.22038/ijp.2014.2719

Abstract

Background: Pancreatic islet transplantation has emerged as a promising treatment for type I diabetes. However, its efficacy is severely hampered due to poor islet engraftment and ... Read More Background: Pancreatic islet transplantation has emerged as a promising treatment for type I diabetes. However, its efficacy is severely hampered due to poor islet engraftment and revascularization, which have been resulted to partially loss of transplanted islets. It has been shown that local delivery of vascular endothelial growth factor (VEGF) could accelerate transplanted islet revascularization, although permanent high level of VEGF may lead to undesirable side effects. In this study we investigated the effects of conditional cell-based delivery of VEGF through collagen-fibrin hydrogel on transplanted islet function and revascularization. Material and Methods: RH6 human embryonic stem cell derived mesenchymal stem cells (ES-MSCs) have been generated, characterized and transduced by two lentiviruses containing rtTA and VEGF-A. Tet-on expression of VEGF from these cells was shown by tube formation assay and was confirmed through VEGF ELISA. After co-transplantation of these cells and mouse isolated islets through collagen-fibrin hydrogel in the omental pouch of diabetic nude mice, the blood glucose, body weight, glucose tolerance and serum C-peptide was measured after 28 days. As control groups, islets were transplanted alone and with non-transgenic ES-MSCs. For measurement of revascularization, immunohistoflourscence examination was done and micro vessel density (MVD) and vessel size have been measured. Results: Receiving the same number of islets (300 IEQ) in all transplanted groups, the average blood glucose concentrations of mice transplanted with islets/hESC-MSC:VEGF were significantly lower than mice transplanted with islets or islet/hESC-MSC at different time points. This notable difference in blood sugar of transplant groups, was also reflected in their weight gain. Serum C-peptide level was higher in islet/hESC-MSC:VEGF (349.8±51.2 pM) compared with islet/hESC-MSC group and islet group but it was not markedly different from C-peptide levels in normal mice. In intraperitoneal glucose tolerance test (IP-GTT) to examine glucose responsiveness of the islet graft, mice in islet/hESC-MSC:VEGF group returned to normoglycemic state at the same rate as normal mice, while mice in islet/hESC-MSC and islet groups responded more slowly and did not return to the normoglycemic state. The results showed improved islet functionality and micro-vessel density in the group of mice received islets with VEGF expressing hESC-MSC, compared with control groups. Conclusion: We conclude that conditional expression of VEGF from hESC-MSCs during islet transplantation could enhance islet functionality and revascularization. This result can be used to improve the outcome of clinical islet transplantation. Keywords:Co-transplantation, Embryonic stem, Mesenchymal stem cells.

Viewpoints of Traditional Iranian Medicine (TIM) about Etiology of Pediatric Constipation

MR Noras; MA Kiani

Volume 2, Issue 2.1 , April 2014, , Pages 56-56

https://doi.org/10.22038/ijp.2014.2516

Abstract

Constipation in children is a common health problem affecting 0.7% to 29.6% children across the world. Exact etiology for developing symptoms is not clear in children and the majority ... Read More

The effect of Dimethyl Sulfoxide on hepatogenic differentiation of Mesenchymal Stem Cells

Effat Alizadeh; Nosratollah Zarghami; Mohammad Reza Baghaban Eslaminejad; Abolfazl Akbarzadeh; Shahrbano Jahangir; Abolfazl Barzegar; Shahryar Hahemzadeh; Abolghasem Mohammadi

Volume 2, Issue 2.3 , May 2014, , Pages 57-57

https://doi.org/10.22038/ijp.2014.2720

Abstract

Background Adipose tissue mesenchymal stem cells (AT-MSCs) are suitable choices in treatment of liver associated diseases. Dimethyl Sulfoxide (DMSO) is an amphipathic molecule ... Read More Background Adipose tissue mesenchymal stem cells (AT-MSCs) are suitable choices in treatment of liver associated diseases. Dimethyl Sulfoxide (DMSO) is an amphipathic molecule with potential of delivering both lipophilic and hydrophilic agents into cells. Few protocols used DMSO for induction of AT-MSCs towards hepatocyte like cells but the effect of DMSO on hepatogenic differentiation were not surveyed, previously. In the present study, we aimed at evaluation of the effect of DMSO in differentiation of AT-MSCs into hepatic lineage. Methods: We isolated MSCs from adipose tissue then multi-potency and surface markers of AT-MSCs was evaluated. Isolated AT-MSCs randomly dispensed in four groups including group 1: HGF treated, 2: HGF+DMSO treated, 3: HGF+ DMSO+ OMS treated, and group control for a period of 3 weeks in the expansion medium without serum, EGF and bFGF was also included in the first stage of inductions. The morphologic changes during induction period was observed with microscopy. The protein levels of albumin and a-fetoprotein (AFP) of the differentiating MSCs was investigated by ELISA and urea production was evaluated by colorimetric assay. The qRT-PCR was performed for quantitation of hepatocyte marker genes including a-fetoprotein (AFP), CK18, HNF4a, and HNF6. The glycogen storage of differentiated cells was visualized by periodic-acid Schiff‘s staining. Results: The results demonstrate that DMSO speeds up hepatic differentiation of AT-MSCs characterized by rapid changes in morphology, higher expression of hepatic marker gene (AFP) in both mRNA and protein level (P<0.05), also, increased transcriptional levels of other hepatic genes including CK18, HNF4a, and HNF6 (P<0.01) moreover, greater percentage of glycogen storage( p< 0.05) in DMSO treated groups. Conclusion: DMSO catalyzes hepatic differentiation, therefore using DMSO for acceleration of the hepatogenic protocols of AT-MSCs appears advantageous. Keywords: Adipose Tissue, Mesenchymal Stem Cells, Hepatic differentiation.

The Effect of International Economic Law on the Process of Political Development of Children's Rights

Abtin Amiri; Mohammad Sadeqi; Seyyed Bagher Mirabbasi; Aboomohammad Asgarkhani

Volume 9, Issue 5 , May 2021, , Pages 13617-13634

https://doi.org/10.22038/ijp.2020.48782.3917

Abstract

International economic law has a transformational role in developing the economy, where the transformation leads to economic prosperity ... Read More

Comparative Study of Frequency and Severity of Neonatal Jaundice without a Known Etiology in Two Groups of Term Neonate Born Via Cesarean Section and Vaginal Delivery

Ash Farhat; L Hafizi; A Mohammadzadeh; M Hasanzadeh; MT Poorhosieni

Volume 2, Issue 2.1 , April 2014, , Pages 57-57

https://doi.org/10.22038/ijp.2014.2517

Abstract

Introduction: Neonatal jaundice has a significant prevalence, and in severe cases, causes permanent neurological Sequela. Many studies have carried out on neonatal jaundice and its ... Read More

Increase of Proliferation and Colonization in Mouse Spermatogonial Stem Cell by Low Intensity Ultrasound

Mahdi Mohaqiq; Mansoureh Movahedin; Manizheh Mokhtari Dizaji; Zohreh Mazaheri

Volume 2, Issue 2.3 , May 2014, , Pages 58-58

https://doi.org/10.22038/ijp.2014.2721

Abstract

Background Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis. Sound wave especially low intensity ultrasound (LIUS) can be effective on increasing the number ... Read More

Gastrointestinal Anomalies in Imam Reza Hospital Deliveries- Mashhad Iran

A Mohammadzadeh; Ash Farhat

Volume 2, Issue 2.1 , April 2014, , Pages 58-58

https://doi.org/10.22038/ijp.2014.2519

Abstract

Introduction: Congenital gastrointestinal (GI) malformation occurs due to mal development of GI organs. The diagnosis is based on clinical exam and radiography. The aim of this study ... Read More

Evaluation of the Effect of Platelet-Rich Plasma on Proliferation and Differentiation of Human Dental Pulp Stem Cells with or without Ga-Al-As Laser

Maryam Bidar

Volume 2, Issue 2.3 , May 2014, , Pages 59-59

https://doi.org/10.22038/ijp.2014.2722

Abstract

Background Recently, the clinical use of low power lasers has increased, and it is said that wound healing is accelerated by their irradiation. The aim of this study was evaluation ... Read More

Assessment the Relationship between Parents' Literacy Level with Children Growth in Mashhad: An Analytic Descriptive Study

Bibi Leila Hoseini; M Saeidi; R Vakili; MA Kiani; M Rabiei; A Khakshour; SM Rasti Sani

Volume 2, Issue 2.1 , April 2014, , Pages 59-59

https://doi.org/10.22038/ijp.2014.2521

Abstract

Introduction: Present children are the investments of community in the future. Preparing children health which leads to the stability of community health, provided to accurate implementation ... Read More

Stem Cell Therapy in Hypoxic Ischemic Encephalopathy

Ashraf Mohammadzadeh; Ahmadshah Farhat

Volume 2, Issue 2.3 , May 2014, , Pages 60-60

https://doi.org/10.22038/ijp.2014.2723

Abstract

Introduction there are one million deaths from asphyxia in newborn annually. Management of this newborn is only supportive. Autologuse stem cell therapy may reduce mortality and long ... Read More

Survey of Effect Peppermint on Pyloric Spasm in Children During Endoscopy

S Partovi; MA Kiani; E Poursoltani; A Khakshour; M Sabbagh

Volume 2, Issue 2.1 , April 2014, , Pages 60-60

https://doi.org/10.22038/ijp.2014.2529

Abstract

Introduction: Gastrointestinal Endoscopy is as a diagnosis and treatment of gastrointestinal diseases in children. Due to severe response and spastic in the muscles of ... Read More

General Anesthesia for Lumbar Puncture and Bone Marrow Aspiration /Biopsy in Children

Ali Ghasemi

Volume 2, Issue 2.3 , May 2014, , Pages 61-61

https://doi.org/10.22038/ijp.2014.2724

Abstract

Background Multiple procedures (Lumbar puncture and bone marrow aspiration /biopsy) cause pain, stress, depression and etc for the patients and their families. Various methods ... Read More

Maternal Knowledge and Practice in Mashhad City about Breast-feeding in First 6 -Month of Infant's Life

S Tehranian; P Shojaee; S Jafarzadeh; HR Kianifar; Sa Jafari

Volume 2, Issue 2.1 , April 2014, , Pages 61-61

https://doi.org/10.22038/ijp.2014.2544

Abstract

Introduction: Breastfeeding is an important principle in pediatric health. It decreases their mortality and protect them fromm diseases in the first 6-month of life. This study aimed ... Read More

Stem Cells of the Dental Pulp

Mahboobe Dehghani

Volume 2, Issue 2.3 , May 2014, , Pages 62-62

https://doi.org/10.22038/ijp.2014.2725

Abstract

Dental Pulp Stem Cells (DPSCs) can be found within the cell rich zone of dental pulp. These stem cells, under specific stimuli, differentiate into many cell types which have wide ... Read More

Effect Supermint oil (Peppermint oil) on the Patient's and Colonoscopy Team Satisfaction During Colonoscopy in Children

A Khodadad; MA Kiani; M Najafi; A Khakshour; M Saeidi; SA Jafari; M Ghayour Mobarhan

Volume 2, Issue 2.1 , April 2014, , Pages 62-62

https://doi.org/10.22038/ijp.2014.2530

Abstract

Introduction: Colonoscopy is an invasive method that is painful for patient especially for children. The objective of this research was investigation of the effect of supermint oral ... Read More

Stem Cell-Based Therapy (Cell Therapy) in Iran and other Countries

Mohammad Mousaei Ghasroldasht; Maryam M.Matin; Hamid Reza Bidkhori; Ahmad Reza Bahrami

Volume 2, Issue 2.3 , May 2014, , Pages 63-63

https://doi.org/10.22038/ijp.2014.2726

Abstract

Cell therapy is a modern approach in the treatment of most of the diseases which uses stem cells and it has been recently developed rapidly. Cell therapy has shown satisfactory results ... Read More

Nonalcoholic Fatty Liver Disease Treatment

M Sadeghian; A Torabi

Volume 2, Issue 2.1 , April 2014, , Pages 63-63

https://doi.org/10.22038/ijp.2014.2531

Abstract

Nonalcoholic fatty liver disease (NAFLD) is increasing in pediatric age group parallel to the growing prevalence of obesity and overweight all around the world. So changing in life ... Read More

Rat Bone Marrow Mesenchymal Stem Cell Differentiation to Insulin Producing Cells and Evaluation their Responses in Vitro and in Vivo

Seyyed Abbas Zojaj; Reza Shafiee-Nick; Ahmad Ghorbani

Volume 2, Issue 2.3 , May 2014, , Pages 64-64

https://doi.org/10.22038/ijp.2014.2727

Abstract

Background In recent years, many researchers haveattempted to cure diabetes by using stem cells technology. Stem cells from different sources have capabilityto differentiateinto ... Read More Background In recent years, many researchers haveattempted to cure diabetes by using stem cells technology. Stem cells from different sources have capabilityto differentiateinto insulin producing cells (IPCs) by different methods. The obstaclesof these methods aretheirexpensive materials and complexity ofmethodswhichare practicallydisadvantagesfor producing enough transplantableIPCs that can cure a diabetic patient. The aim of present study was to test a method for isolation and differentiation of rat bone marrow mesenchymal stem cells (BMSC)into IPCs which is simple method and produce abundant IPCs. Methods: Adult male Wistar rats 4-6 weeks age and 200-250 g weight were used. Bone marrow was isolated from femoral bone under asepticconditionand cultured as monolayerin DMEM in a density of 1×106/well at 37ºC and 5% CO2 for72 h. After three passages, the cells were differentiated into adiposities and osteocyte cells which approved using oil red and alizarin red staining, respectively. To produce IPCs, BMSC was cultured in low glucose DMEM, with 1% DMSO and without FBS for three days on collagenated coverslips. After three days, theculture medium was changedto DMEM containing 25 mM glucose plus10%FBS and incubated for 7 days. For assessment of insulin secretion capabilityof IPCs, the cells were incubated in DMEM containing5.5 or 25 mM glucose with or without IBMX for two hours. Samples from the medium were taken for subsequent insulin assay For in vivo assay, the mice were made diabetic by injection 200 mg/kgstreptozocinintraperitoneally,which produced a fasting blood sugar about 450 mg/dl. For each mouse, 105 IPCs were injectedintraperitonally. Control mice were injected with 100 µl normal saline.The mice blood sugars were checked every 3 days with a glocoumeter device. Results: The content of secreted insulin in 5.5 m M glucose concentration was about 40miu/ml that raised to72 miu/ml with incubation with 25 mM glucose. The insulin secretion was potentiated by IBMX which increased to 104miu/ml. One week after IPC transplantation to diabetic mice, fasting blood sugar was started to decrease. After two weeks of transplantation, the blood glucose was fallen to 265 mg/dL comparing to control mice which their fasting blood sugar was about 450 mg/dl until end of study. Conclusion: In this study we introduced a simple, valuable and low cost method to produce insulin producing cells from bone marrow mesenchymal stem cells which could be translated into human clinical trials. Keywords: Mesenchymal stem cells, Transplantation, Diabetes.

Posterior Kyphectomy in a Myelomeningocele Patient with Gibbous Deformity: A Case Report and Literature Review

Ehsan Keykhosravi; Amin Tavallaii; Masood Pishjoo; Behzad Aminzadeh; Mona Maftouh; Mohammad Ali Abouei Mehrizi; Mohammadreza Shahmohammadi; Hamid Rezaee

Volume 8, Issue 11 , November 2020, , Pages 12517-12522

https://doi.org/10.22038/ijp.2020.48810.3920

Abstract

Myelomeningocele is a condition caused by the disjunction of neuroectoderm and ectoderm during embryogenesis. It can lead to neuronal structure disorders such as kyphosis and scoliosis, ... Read More

Mebeverine for Pediatric Functional Abdominal Pain: A Randomized, Placebo-Controlled Trial

Z Pourmoghaddas; H Saneian; H Roohafza; A Gholamrezaei

Volume 2, Issue 2.1 , April 2014, , Pages 64-64

https://doi.org/10.22038/ijp.2014.2532

Abstract

Introduction: Few studies are conducted on the efficacy of antispasmodics in the treatment of functional gastrointestinal disorders in children. We evaluated the effectiveness of ... Read More

Volume 12 (2024)

Volume 11 (2023)

Volume 10 (2022)

Volume 9 (2021)

Volume 8 (2020)

Volume 7 (2019)

Volume 6 (2018)

Volume 5 (2017)

Volume 4 (2016)

Volume 3 (2015)

Volume 2 (2014)

Volume 1 (2013)

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