Noor Mohammad Noori; Amer Yazdanparast; Maryam Nakhaee Moghaddam; Alireza Teimouri
Abstract
Background Respiratory Distress (RD) is a life-threatening respiratory failure. This study aimed to evaluate the diagnostic value of N-terminal prohormone of brain natriuretic peptide ...
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Background Respiratory Distress (RD) is a life-threatening respiratory failure. This study aimed to evaluate the diagnostic value of N-terminal prohormone of brain natriuretic peptide (NT-pro-BNP) in distinguishing respiratory and heart diseases in neonates. Materials and Methods Hundred fifty neonates aged 2-3 days randomly collected from those who hospitalized in the related ward of the Ali Ebne Abitaleb Hospital, Zahedan, Iran. After sampling 2ml blood from venipuncture by trained nurse in the related ward separated serums performed in a laboratory. Then, 250 μl of the patients’ serum was isolated to assess NT- pro-BNP level using ELISA kit (USA). Data were analyzed using SPSS software version 20.0 with considering of P< 0.05. Results Mean of NT-pro-BNP in respiratory, Acyanotic, cyanotic and controls were 386.22±208.82, 384.83±183.74, 372.23±143.04, and 161.70-± 121.2, respectively. Weight, height and head circumference had different mean ranks for respiratory, Acyanotic, cyanotic and healthy groups, respectively (P<0.05). Conclusion According to the results, despite of some reports, NT-proBNP is good biomarker to determine differentiate between cardiac and respiratory during neonate.
