Document Type : original article

Authors

1 Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2 Pediatric Health Research Center, Department of Pediatrics, Tabriz University of Medical Sciences, Tabriz, Iran.

3 Clinical Research Development Unit of Children Educational and Treatment Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Introduction: Diabetes mellitus is the most common childhood metabolic disease whose prevalence has been increasing worldwide in recent decades. Diabetic nephropathy is one of the most important chronic complications of both types of diabetes (type 1 and 2), which seriously increases the morbidity and mortality of diabetes. The present study evaluated the epidemiology and risk factors of diabetic nephropathy in children with diabetes in the northwestern region of Iran.

Method: In this cross-sectional study, 80 diabetic children with a mean age of 16.69±4.50 years have been studied in the endocrinology clinic of Tabriz Children's Hospital from 2000 to 2015. Children were divided into two groups based on the presence or absence of albuminuria, and different variables have been compared between the two groups to determine risk factors.

Results: The mean age at the diagnosis was 7.75±3.69 and the mean duration of diabetes was 8.98±4.07 years. Good glycemic control was presented in 19(23.8%), microalbuminuria in 36(45%), overt albuminuria in 1(1.3%), and retinopathy in 5(6.3%) of patients; 7(8.8%) had hypertension. Chronic kidney disease was found to be stage I in 90% and stage II in 10% of patients. There was a significant difference between cases with and without albuminuria in terms of age at the time of the study (p=0.003), duration of diabetes (p=0.02), and serum cholesterol level (p=0.04). Linear Regression test showed that «age at diagnosis» has a significant ability to predict the incidence of albuminuria (p=0.03).

Conclusion: Renal function of diabetic children and adolescents should be periodically evaluated, especially in older patients, those with longer duration of diabetes or poor glycemic control.

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