Document Type : original article


1 Pediatric resident in Mashhad University of Medical Sciences

2 Clinical Research Development Unit of Akbar Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


Oral Immunotherapy (OIT) is an effective strategy for improving food allergy tolerance. OIT has been introduced as a novel immune-modulating medication for food allergies. Other immunomodulatory approaches, such as sublingual (SLIT) or epicutaneous (EPIT) immunotherapy, may be less effective due to lower frequencies of systemic responses. Wheat and milk have lately been identified as a more prevalent cause of food-induced anaphylaxis than previously thought, particularly in young children worldwide. An immunoglobulin E (IgE)-dependent pathway may be responsible for wheat or milk allergy. The goal of our study was to offer a comprehensive evaluation of the effects of OIT in children with IGE-dependent food allergies to milk or wheat. Keywords related to OIT, food allergy, milk, wheat, and children were searched in MEDLINE, PubMed, Google Scholar, and ScienceDirect databases. Although oral immunotherapy for wheat allergy has recently been proposed, research studies have had encouraging results; despite, more research is still needed to determine the optimum strategy for promoting tolerance in wheat/milk-allergic children


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